Polygenic prediction of the phenome, across ancestry, in emerging adulthood.

ABSTRACT: BACKGROUND:Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes. METHODS:This study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes. RESULTS:Polygenic risk

SUBMITTER: Docherty AR 

PROVIDER: S-EPMC5971142 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature