NF-κB1 Rs28362491 Mutant Allele Frequencies along the Silk Road and Beyond.

ABSTRACT:

Background

In the human evolutionary history, Single Nucleotide Polymorphism (SNP) frequencies are valuable in terms of finding connections between different populations. Due to the pronounced role of the immune system in combating pathogens and environmental stressors, polymorphisms in the immune genes are subject to selection pressure of the diseases as well. The functional polymorphisms in NF-κB1 promoter (-94 ins/del) are associated with different diseases; therefore, we aimed to establish the frequencies of NF-κB1 rs28362491 alleles in a population of Southwestern Iranians in comparison with the world populations.

Methods

We assessed the polymorphism of -94 ATTG ins/del (rs28362491) in 201 Iranian healthy blood donors from Fars Province, central Iran in a one year perio

SUBMITTER: Pordel S 

PROVIDER: S-EPMC5971177 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature