Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

ABSTRACT:

Background

A serious adverse effect of corticosteroid therapy is adrenal suppression. Our aim was to identify genetic variants affecting susceptibility to corticosteroid-induced adrenal suppression.

Methods

We enrolled children with asthma who used inhaled corticosteroids as part of their treatment from 25 sites across the UK (discovery cohort), as part of the Pharmacogenetics of Adrenal Suppression with Inhaled Steroids (PASS) study. We included two validation cohorts, one comprising children with asthma (PASS study) and the other consisting of adults with chronic obstructive pulmonary disorder (COPD) who were recruited from two UK centres for the Pharmacogenomics of Adrenal Suppression in COPD (PASIC) study. Participants underwent a low-dose short synacthen test. Adrenal s

SUBMITTER: Hawcutt DB 

PROVIDER: S-EPMC5971210 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature