Relapse Rate and MRI Activity in Young Adult Patients With Multiple Sclerosis: A Post Hoc Analysis of Phase 3 Fingolimod Trials.

ABSTRACT:

Background

Disease activity differs in young patients with multiple sclerosis (MS) compared with the overall adult MS population.

Objective

The objective of this paper is to evaluate the effect of fingolimod 0.5 mg on disease activity in young adults with MS from three randomized, double-blind Phase 3 trials.

Methods

Annualized relapse rate (ARR), number of new/newly enlarging T2 lesions (neT2), and no evidence of disease activity (NEDA-3) were estimated in the intent-to-treat population at age 20 (youngest) and 30 (young) and compared to the overall population. Models used included a negative binomial regression (ARR/neT2) and a logistic regression (NEDA), with age at baseline as a continuous covariate.

Results

ARRs were higher in younger patients (all p

SUBMITTER: Gartner J 

PROVIDER: S-EPMC5971396 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature