Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort.

ABSTRACT:

Background

The relationship between long-term exposure to whole body or central obesity and cognitive function, as well as its potential determinants, remain controversial. In this study, we assessed (1) the potential impact of 30 years exposure to different patterns of whole body and central adiposity on cognitive function at 60-64 years, (2) whether trajectories of central adiposity can provide additional information on later cognitive function compared to trajectories of whole body adiposity, and (3) the influence of vascular phenotypes on these associations.

Methods

The study included 1249 participants from the prospective cohort MRC National Survey of Health and Development. Body mass index (BMI), waist circumference (WC), and vascular (carotid intima-media thickness, c

SUBMITTER: Masi S 

PROVIDER: S-EPMC5971427 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature