Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina.

ABSTRACT: BACKGROUND:In contrast to mammals, zebrafish have the capacity to regenerate retinal neurons following a variety of injuries. Two types of glial cells, Müller glia (MG) and microglia, are known to exist in the zebrafish retina. Recent work has shown that MG give rise to regenerated retinal neurons, but the role of resident microglia, and the innate immune system more generally, during retinal regeneration is not well defined. Specifically, characteristics of the immune system and microglia following substantial neuron death and a successful regenerative response have not been documented. METHODS:The neurotoxin ouabain was used to induce a substantial retinal lesion of the inner retina in zebrafish. This lesion results in a regenerative response that largely restores retinal architecture, n

SUBMITTER: Mitchell DM 

PROVIDER: S-EPMC5971432 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature