Measurement of Skeletal Muscle Area Improves Estimation of Aminoglycoside Clearance across Body Size.

ABSTRACT: A consistent approach to the dosing of aminoglycosides across the modern body size distribution has been elusive. We evaluated whether radiologically derived measures of body composition could explain more of the interpatient variability in aminoglycoside pharmacokinetics (PK) than standard body size metrics. This retrospective study included adult patients treated with gentamicin or tobramycin with at least three drug concentrations and computed tomography (CT) imaging available. Aminoglycoside volume and clearance (CL) estimates were computed using a two-compartment model by Bayesian analysis. Morphomic data were extracted from CT images using a custom algorithm. Bivariable and multivariable linear regression were used to assess relationships between PK parameters and covariates. A total

SUBMITTER: Crass RL 

PROVIDER: S-EPMC5971580 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature