Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.

ABSTRACT: Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade the rate of azole resistance among Aspergillus fumigatus strains has increased notoriously. The main resistance mechanisms are well defined and mostly related to point mutations of the azole target, 14-α sterol demethylase (cyp51A), with or without tandem repeat integrations in the cyp51A promoter. Furthermore, different combinations of five Cyp51A mutations (F46Y, M172V, N248T, D255E, and E427K) have been reported worldwide in about 10% of all A. fumigatus isolates tested. The azole susceptibility profile of these strains shows elevated azole MICs, although on the basis of the azole susceptibility breakpoints, these strains are not considered azo

SUBMITTER: Garcia-Rubio R 

PROVIDER: S-EPMC5971592 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature