Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.

ABSTRACT: The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.

SUBMITTER: Feng G 

PROVIDER: S-EPMC5971662 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature