Evolution of substrate specificity in the Nucleobase-Ascorbate Transporter (NAT) protein family.

ABSTRACT: L-ascorbic acid (vitamin C) is an essential metabolite in animals and plants due to its role as an enzyme co-factor and antioxidant activity. In most eukaryotic organisms, L-ascorbate is biosynthesized enzymatically, but in several major groups, including the primate suborder Haplorhini, this ability is lost due to gene truncations in the gene coding for L-gulonolactone oxidase. Specific ascorbate transporters (SVCTs) have been characterized only in mammals and shown to be essential for life. These belong to an extensively studied transporter family, called Nucleobase-Ascorbate Transporters (NAT). The prototypic member of this family, and one of the most extensively studied eukaryotic transporters, is UapA, a uric acid-xanthine/H⁺ symporter in the fungus Aspergillus nidulans<

SUBMITTER: Kourkoulou A 

PROVIDER: S-EPMC5972032 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature