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Dual Transforming Growth Factor-β and Programmed Death-1 Blockade: A Strategy for Immune-Excluded Tumors?

ABSTRACT: Tumors that elude infiltration by CD8+ T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal transforming growth factor (TGF)-β appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-excluded neoplasms.

SUBMITTER: Vanpouille-Box C 

PROVIDER: S-EPMC5972064 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Dual Transforming Growth Factor-β and Programmed Death-1 Blockade: A Strategy for Immune-Excluded Tumors?

Vanpouille-Box Claire C   Formenti Silvia C SC  

Trends in immunology 20180326 6

Tumors that elude infiltration by CD8<sup>+</sup> T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal transforming growth factor (TGF)-β appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-excluded neoplasms. ...[more]

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