Maternal/fetal metabolomes appear to mediate the impact of arsenic exposure on birth weight: A pilot study.

ABSTRACT: Arsenic exposure has been associated with low birth weight. However, the underlying mechanisms are not well understood. Alterations to metabolites may act as causal mediators of the effect of arsenic exposure on low birth weight. This pilot study aimed to explore the role of metabolites in mediating the association of arsenic exposure on infant birth weight. Study samples were selected from a well-established prospectively enrolled cohort in Bangladesh comprising 35 newborns and a subset of 20 matched mothers. Metabolomics profiling was performed on 35 cord blood samples and 20 maternal peripheral blood samples collected during the second trimester of pregnancy. Inorganic arsenic (iAs) exposure was evaluated via cord blood samples and maternal toenail samples collected during the first tri

SUBMITTER: Wei Y 

PROVIDER: S-EPMC5972365 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature