Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences.

ABSTRACT: In many organisms, telomeric sequences can be located internally on the chromosome in addition to their usual positions at the ends of the chromosome. In humans, such interstitial telomeric sequences (ITSs) are nonrandomly associated with translocation breakpoints in tumor cells and with chromosome fragile sites (regions of the chromosome that break in response to perturbed DNA replication). We previously showed that ITSs in yeast generated several different types of instability, including terminal inversions (recombination between the ITS and the "true" chromosome telomere) and point mutations in DNA sequences adjacent to the ITS. In the current study, we examine the genetic control of these events. We show that the terminal inversions occur by the single-strand annealing pathway of DNA r

SUBMITTER: Moore A 

PROVIDER: S-EPMC5972418 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature