Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: an observational cohort study.

ABSTRACT:

Background

The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a control group remaining on triple antiretroviral therapy (ART).

Methods

We included patients in Icona who started a three-drug combination ART regimen from an ART-naïve status and achieved a viral load ≤ 50 copies/mL; they were subsequently switched to another triple or to a mono or double regimen. Standard linear regression at fixed points in time (12-24 months after the switch) and linear mixed model analysis with random intercepts and slopes were used to compare CD4 and CD8 counts and their ratio over time according to regimen types (triple vs. dual and vs.

SUBMITTER: Mussini C 

PROVIDER: S-EPMC5972434 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature