Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury.

ABSTRACT:

Background

White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury.

Methods

We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis.

Results

On top of all conventional MRI markers combined, MD of the whole brain white matter explained an additional 3.4% (p = 0.014

SUBMITTER: Biesbroek JM 

PROVIDER: S-EPMC5972515 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature