Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.

ABSTRACT: Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as "targeted therapies") and those that center on enhancing the capacity of a patient's immune system to mount an antitumor response (immunotherapy). Maximizing responses to both of these approaches requires an understanding of the oncogenic events present in a given patient's tumor and the nature of the tumor-immune microenvironment. Although these 2 modalities were developed and initially used independently, combination regimens are now being tested in clinical trials, underscoring the need to understand how targeted therapies influence immunologic events. Translational studies

SUBMITTER: Kersh AE 

PROVIDER: S-EPMC5972536 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature