Interleukin-7 Unveils Pathogen-Specific T Cells by Enhancing Antigen-Recall Responses.

ABSTRACT:

Background

Interleukin (IL)-7 promotes the generation, expansion, and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-reactive T cells for adoptive immunotherapy, and enhance effector cytokine expression by autoreactive T cells. Whether pathogen-reactive T cells also benefit from IL-7 exposure remains unknown.

Methods

In this study, we investigated this issue in cultures of peripheral blood mononuclear cells (PBMCs) derived from patients infected with various endemic pathogens. After short-term exposure to IL-7, we measured PBMC responses to antigens derived from pathogens, such as Mycobacterium tuberculosis, Candida albicans, and cytomegalovirus, and to the superanti

SUBMITTER: Terrazzini N 

PROVIDER: S-EPMC5972594 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature