Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?

ABSTRACT:

Study question

Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated?

Summary answer

LGR5 expressing cells are not limited to the postulated stem cell niche but LGR5 expression is hormonally regulated.

What is known already

The human endometrium is a highly regenerative tissue; however, endometrial epithelial stem cell markers are yet to be confirmed. LGR5 is a marker of stem cells in various epithelia.

Study design, size, duration

The study was conducted at a University Research Institute. Endometrial samples from 50 healthy women undergoing benign gynaecological surgery with no endometrial pathology at

SUBMITTER: Tempest N 

PROVIDER: S-EPMC5972618 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature