HOPE: Hybrid-Drive Combining Optogenetics, Pharmacology and Electrophysiology.

ABSTRACT: Understanding the neural mechanisms underlying human cognition and determining the causal factors for the development of brain pathologies are among the greatest challenges for society. Electrophysiological recordings offer remarkable observations of brain activity as they provide highly precise representations of information coding in both temporal and spatial domains. With the development of genetic tools over the last decades, mice have been a key model organism in neuroscience. However, conducting chronic in vivo electrophysiology in awake, behaving mice remains technically challenging, and this difficulty prevents many research teams from acquiring critical recordings in their mouse models. Behavioral training, implant fabrication, brain surgery, data acquisition and data analysis are

SUBMITTER: Delcasso S 

PROVIDER: S-EPMC5972628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature