G2S: a web-service for annotating genomic variants on 3D protein structures.

ABSTRACT: Motivation:Accurately mapping and annotating genomic locations on 3D protein structures is a key step in structure-based analysis of genomic variants detected by recent large-scale sequencing efforts. There are several mapping resources currently available, but none of them provides a web API (Application Programming Interface) that supports programmatic access. Results:We present G2S, a real-time web API that provides automated mapping of genomic variants on 3D protein structures. G2S can align genomic locations of variants, protein locations, or protein sequences to protein structures and retrieve the mapped residues from structures. G2S API uses REST-inspired design and it can be used by various clients such as web browsers, command terminals, programming languages and other bioinformat

SUBMITTER: Wang J 

PROVIDER: S-EPMC5972642 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature