Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.

ABSTRACT: Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Although it has been extensively studied, the proximate trigger of the immune response remains uncertain. Experimental autoimmune encephalomyelitis in the common marmoset recapitulates many radiological and pathological features of focal multiple sclerosis lesions in the cerebral white matter, unlike traditional experimental autoimmune encephalomyelitis in rodents. This provides an opportunity to investigate how lesions form as well as the relative timing of factors involved in lesion pathogenesis, especially during early stages of the disease. We used MRI to track experimental autoimmune encephalomyelitis lesions in vivo to determine their age, stage of development, and location, and we assessed the

SUBMITTER: Lee NJ 

PROVIDER: S-EPMC5972667 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature