Identification and Characterization of Sindbis Virus RNA-Host Protein Interactions.

ABSTRACT: Arthropod-borne viruses, such as the members of the genus Alphavirus, are a significant concern to global public health. As obligate intracellular pathogens, RNA viruses must interact with the host cell machinery to establish and complete their life cycles. Despite considerable efforts to define the host-pathogen interactions essential for alphaviral replication, an unbiased and inclusive assessment of alphaviral RNA-protein interactions has not been undertaken. Moreover, the biological and molecular importance of these interactions, in the full context of their molecular function as RNA-binding proteins, has not been fully realized. The data presented here introduce a robust viral RNA-protein discovery method to elucidate the Sindbis virus (SINV) RNA-protein host interface. Cross-l

SUBMITTER: LaPointe AT 

PROVIDER: S-EPMC5972874 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature