Association of FGFR2 and PI3KCA genetic variants with the risk of breast cancer in a Chinese population.

ABSTRACT:

Purpose

Genome-wide association studies have found plenty of single nucleotide polymorphisms (SNPs) which are associated with breast cancer risk. SNPs in FGFR2 are mostly identified. However, the association between PI3KCA SNP and breast cancer risk remains largely unknown. The aim of this study was to investigate the significance of FGFR2 and PI3KCA genetic variants in breast cancer and their association with prognosis.

Methods

We performed genotyping of 328 breast cancer patients and 389 healthy controls. Then, we evaluated the associations of FGFR2 rs1219648 and PI3KCA rs6443624 with the susceptibility and clinicopathological features of breast cancer. Kaplan-Meier curve with log-rank test was performed to determine the prognostic values of FGFR2 rs1219648 and PI3KCA rs64

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5973406 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature