Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca^-/- and Fancg^-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).

ABSTRACT: Squamous cell carcinomas of the head and neck are appearing with increased frequency in both marrow transplanted and non-transplanted Fanconi anemia (FA) patients. FA patients commonly display radiosensitivity of epithelial tissues, complicating effective radiotherapy. Fancd2^-/- mice (C57BL/6J and 129/Sv background) demonstrate epithelial tissue sensitivity to single-fraction or fractionated irradiation to the head and neck and distant marrow suppression (abscopal effect), both ameliorated by intraoral administration of the mitochondrial-targeted antioxidant, GS-nitroxide, JP4-039. We now report that mice of two other FA genotypes, Fancg^-/- (B6) and the most prevalent human genotype Fanca^-/- (129/Sv), also demonstrate: 1. reduced longevity of hematopoiesis

SUBMITTER: Willis J 

PROVIDER: S-EPMC5973476 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature