Temporal blood flow changes measured by diffuse correlation tomography predict murine femoral graft healing.

ABSTRACT: Blood flow changes during bone graft healing have the potential to provide important information about graft success, as the nutrients, oxygen, circulating cells and growth factors essential for integration are delivered by blood. However, longitudinal monitoring of blood flow changes during graft healing has been a challenge due to limitations in current techniques. To this end, non-invasive diffuse correlation tomography (DCT) was investigated to enable longitudinal monitoring of three-dimensional blood flow changes in deep tissue. Specific to this study, longitudinal blood flow changes were utilized to predict healing outcomes of common interventions for massive bone defects using a common mouse femoral defect model. Weekly blood flow changes were non-invasively measured using a diffuse

SUBMITTER: Han S 

PROVIDER: S-EPMC5973582 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature