Resistance screening and trend analysis of imported falciparum malaria in NSW, Australia (2010 to 2016).

ABSTRACT:

Background

The World Health Organization currently recommends artemisinin (along with a partner drug) as the global frontline treatment for Plasmodium falciparum malaria. Artemisinin resistant P. falciparum are now found throughout the greater Mekong subregion of South East Asia. Several polymorphisms in the parasite's kelch gene have been demonstrated to confer artemisinin resistance. While genotypes within the greater Mekong subregion are thoroughly examined in the literature, P. falciparum populations within several areas that do not (yet) have endemic resistance are underrepresented.

Results

This investigation characterised the Pfkelch13 propeller domains from 153 blood samples of 140 imported cases of P. falciparum malaria in New South Wales from 2010 to 2016. A low lev

SUBMITTER: Prosser C 

PROVIDER: S-EPMC5973583 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature