Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study).

ABSTRACT:

Background and purpose

Emerging evidence suggests that an underlying atrial cardiopathy may result in thromboembolism before atrial fibrillation (AF) develops. We examined the association between various markers of atrial cardiopathy and the risk of ischemic stroke.

Methods

The CHS (Cardiovascular Health Study) prospectively enrolled community-dwelling adults ≥65 years of age. For this study, we excluded participants diagnosed with stroke or AF before baseline. Exposures were several markers of atrial cardiopathy: baseline P-wave terminal force in ECG lead V₁, left atrial dimension on echocardiogram, and N terminal pro B type natriuretic peptide (NT-proBNP), as well as incident AF. Incident AF was ascertained from 12-lead electrocardiograms at annual study visits

SUBMITTER: Kamel H 

PROVIDER: S-EPMC5973804 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature