Major depression, antidepressant use, and male and female fertility.

ABSTRACT:

Objective

To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments.

Design

Cohort study.

Setting

Clinics.

Patient(s)

Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins versus clomiphene citrate versus letrozole for unexplained infertility).

Intervention(s)

Female and male partners completed the Patient Health Questionnaire (PHQ-9). Female medication use was collected. PHQ-9 score ≥10 was used to define currently active MD.

Main outcome measure(s)

Primary outcome: live birth.

Secondary outcomes

pregnancy, first-trimester miscarriage. Poisson regression

SUBMITTER: Evans-Hoeker EA 

PROVIDER: S-EPMC5973807 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature