MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca²⁺ Stress.

ABSTRACT: Mitochondria shape cytosolic calcium ([Ca²⁺]_c) transients and utilize the mitochondrial Ca²⁺ ([Ca²⁺]_m) in exchange for bioenergetics output. Conversely, dysregulated [Ca²⁺]_c causes [Ca²⁺]_m overload and induces permeability transition pore and cell death. Ablation of MCU-mediated Ca²⁺ uptake exhibited elevated [Ca²⁺]_c and failed to prevent stress-induced cell death. The mechanisms for these effects remain elusive. Here, we report that mitochondria undergo a cytosolic Ca²⁺-induced shape change that is distinct from mitochondrial fission and swelling. [Ca²⁺]_c elevation, but not MCU-mediated Ca²⁺ uptake, appears to be es

SUBMITTER: Nemani N 

PROVIDER: S-EPMC5973819 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature