Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis.

ABSTRACT:

Background

Tumor-associated immune cells are prognostic in non-small cell lung cancer (NSCLC) but findings have been conflicting.

Objectives

To determine the prognostic role of immune cells according to localization in NSCLC patients.

Methods

A systematic literature review and meta-analysis was performed on dendritic cell (DC), tumor associated macrophages (TAM), mast cells (MC), natural killer (NK) cells, T and B cells and tumor CTLA-4 and PD-L1 studies.

Results

We analysed 96 articles (n= 21,752 patients). Improved outcomes were seen with increased tumor DCs (overall survival (OS) hazard ratio (HR) 0.55; 95% confidence interval (CI) 0.44-0.68), NK cells (OS HR 0.45; 0.31-0.65), TAMs (OS HR 0.33; 0.17-0.62), M1 TAMs (OS HR 0.10; 0.05-0.21), CD3+ T cells

SUBMITTER: Soo RA 

PROVIDER: S-EPMC5973851 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature