Prognostic value of Midkine expression in patients with solid tumors: a systematic review and meta-analysis.

ABSTRACT:

Background

Accumulated studies have shown the important role of Midkine (MDK) protein in various solid tumors and indicated its correlation with patients' survival. This meta-analysis was performed to further explore the prognostic value of MDK expression in solid tumors.

Materials and methods

We collected the literatures through searching PubMed, Embase and the Cochrane Library (last up to April 10, 2017) to assess the effect of MDK on survival in solid tumor patients. The STATA 12.0 software was used for the meta-analysis. Fixed-effects models or random-effects models were used to estimate the pooled hazard ratios (HRs) for overall survival (OS).

Results

A total of 2097 patients from 17 observational studies were summarized. High expression of MDK was notably associ

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5973861 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature