The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4⁺ T Cells During Viral Infection.

ABSTRACT: Follicular helper CD4⁺ T (T_FH) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and sustaining germinal center reactions. The differentiation of T_FH cells relies on multiple intrinsic and extrinsic factors; however, the details by which these factors are integrated to coordinate T_FH differentiation are largely unknown. In this study, using a mouse model of acute lymphocytic choriomeningitis virus (LCMV) viral infection, we demonstrate that mTOR complex 2 (mTORC2) kinase integrates TCR signaling and ICOS-mediated co-stimulation to promote late differentiation and functional maturation of virus-specific T_FH cells. Specifically, mTORC2 functions to maintain T_FH lineage specifications, incl

SUBMITTER: Hao Y 

PROVIDER: S-EPMC5974104 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature