Sub-threshold signal encoding in coupled FitzHugh-Nagumo neurons.

ABSTRACT: Despite intensive research, the mechanisms underlying the neural code remain poorly understood. Recent work has focused on the response of a single neuron to a weak, sub-threshold periodic signal. By simulating the stochastic FitzHugh-Nagumo (FHN) model and then using a symbolic method to analyze the firing activity, preferred and infrequent spike patterns (defined by the relative timing of the spikes) were detected, whose probabilities encode information about the signal. As not individual neurons but neuronal populations are responsible for sensory coding and information transfer, a relevant question is how a second neuron, which does not perceive the signal, affects the detection and the encoding of the signal, done by the first neuron. Through simulations of two stochastic FHN neurons

SUBMITTER: Masoliver M 

PROVIDER: S-EPMC5974132 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature