Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner.

ABSTRACT: Liver is an important secretory organ that consistently manages various insults in order to retain whole-body homeostasis. Importantly, it was suggested that the tumor-suppressor p53 plays a role in a variety of liver physiological processes and thus it is being regarded as a systemic homeostasis regulator. Using high-throughput mass spectrometric analysis, we identified various p53-dependent liver secretome profiles. This allowed a global view on the role of p53 in maintaining the harmony of liver and whole-body homeostasis. We found that p53 altered the liver secretome differently under various conditions. Under physiological conditions, p53 controls factors that are related mainly to lipid metabolism and injury response. Upon exposure to various types of cancer therapy agents, the hepat

SUBMITTER: Charni-Natan M 

PROVIDER: S-EPMC5974134 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature