Quantitative Analysis of the Spatial Organization of Synaptic Inputs on the Postsynaptic Dendrite.

ABSTRACT: The spatial organization of synaptic inputs on the dendritic tree of cortical neurons is considered to play an important role in the dendritic integration of synaptic activity. Active electrical properties of dendrites and mechanisms of dendritic integration have been studied for a long time. New technological developments are now enabling the characterization of the spatial organization of synaptic inputs on dendrites. However, quantitative methods for the analysis of such data are lacking. In order to place cluster parameters into the framework of dendritic integration and synaptic summation, these parameters need to be assessed rigorously in a quantitative manner. Here I present an approach for the analysis of synaptic input clusters on the dendritic tree that is based on combinatorial

SUBMITTER: Scheuss V 

PROVIDER: S-EPMC5974225 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature