The Usage of Exon-Exon Splice Junctions for the Detection of Alternative Splicing using the REIDS model.

ABSTRACT: Alternative gene splicing is a common phenomenon in which a single gene gives rise to multiple transcript isoforms. The process is strictly guided and involves a multitude of proteins and regulatory complexes. Unfortunately, aberrant splicing events have been linked to genetic disorders. Therefore, understanding mechanisms of alternative splicing regulation and differences in splicing events between diseased and healthy tissues is crucial in advancing personalized medicine and drug developments. We propose a linear mixed model, Random Effects for the Identification of Differential Splicing (REIDS), for the identification of alternative splicing events using Human Transcriptome Arrays (HTA). For each exon, a splicing score is calculated based on two scores, an exon score and an array score.

SUBMITTER: Van Moerbeke M 

PROVIDER: S-EPMC5974242 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature