Induction of anergic or regulatory tumor-specific CD4⁺ T cells in the tumor-draining lymph node.

ABSTRACT: CD4⁺ T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human cancers are not secreted. The fate of Ag-specific CD4⁺ T cells recognizing a cytoplasmic Ag in mice bearing autochthonous tumors is still unclear. Here we show, using a genetically engineered lung adenocarcinoma mouse model, that naive tumor-specific CD4⁺ T cells are activated and proliferate in the tumor-draining lymph node (TdLN) but do not differentiate into effectors or accumulate in tumors. Instead, these CD4⁺ T cells are driven toward anergy or peripherally-induced Treg (pTreg) differentiation, from the early stage of tumor development. This bias toward immune suppression is restricte

SUBMITTER: Alonso R 

PROVIDER: S-EPMC5974295 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature