Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine.

ABSTRACT: Evidence from human and animal studies suggests that chronic behavioral stress and resulting activation of the sympathetic nervous system may influence initiation and progression of tumors. However, the underlying mechanisms for these observations are poorly understood. The purpose of this study is to explore the effects of adrenergic signaling on cell line models derived from normal cells presumed to originate epithelial ovarian cancers. Here we explored the effects of the stress-related hormone, norepinephrine, on the transcriptional program of normal immortalized ovarian (iOSE) and fallopian tube (iFTSEC) surface epithelial cells. Analysis of RNA-Seq data of treated and untreated cells revealed a significant overlap between the responses in iOSE and iFTSEC cells. Most genes modulated by

SUBMITTER: Gjyshi A 

PROVIDER: S-EPMC5974302 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature