Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population.

ABSTRACT: We previously showed that a common genetic variant leads to a remarkably increased risk of type 2 diabetes (T2D) in the small and historically isolated Greenlandic population. Motivated by this, we aimed at discovering novel genetic determinants for glycated hemoglobin (HbA_1C) and at estimating the effect of known HbA_1C-associated loci in the Greenlandic population. We analyzed genotype data from 4049 Greenlanders generated using the Illumina Cardio-Metabochip. We performed the discovery association analysis by an additive linear mixed model. To estimate the effect of known HbA_1C-associated loci, we modeled the effect in the European and Inuit ancestry proportions of the Greenlandic genome (EAPGG and IAPGG, respectively). After correcting for multiple testi

SUBMITTER: Appel EVR 

PROVIDER: S-EPMC5974304 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature