MTOR coordinates transcriptional programs and mitochondrial metabolism of activated T_reg subsets to protect tissue homeostasis.

ABSTRACT: Regulatory T (T_reg) cells derived from the thymus (tT_reg) and periphery (pT_reg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of T_reg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis and functional activation of tT_reg and pT_reg cells. mTOR signaling is crucial for programming activated T_reg-cell function to protect immune tolerance and tissue homeostasis. T_reg-specific deletion of mTOR drives spontaneous effector T-cell activation and inflammation in barrier tissues and is associated with reduction in both thymic-derived effector T_reg (eT_reg) and

SUBMITTER: Chapman NM 

PROVIDER: S-EPMC5974344 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature