Lack of significant association between selected STAT3 polymorphisms and rheumatoid arthritis in the Polish population.

ABSTRACT:

Objectives

Rheumatoid arthritis (RA) is the most common systemic inflammatory disease and is of unknown etiology. The altered balance between immunosuppressive and inflammatory T cell subpopulations exerts a huge impact on RA pathogenesis. The STAT3 protein regulates genes involved in the immune responses. It regulates maturation of T and B cells. Its abnormal activity is significantly associated with autoimmune diseases and cancer development. We aimed to evaluate the contribution of three potentially functional single nucleotide polymorphisms (SNPs) within the STAT3 gene to susceptibility and severity of RA in the Polish population.

Material and methods

A total of 595 patients with RA and 330 healthy individuals were included in the study. DNA from patients a

SUBMITTER: Stypinska B 

PROVIDER: S-EPMC5974628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature