Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array.

ABSTRACT: Scalable immunoassay multiplexing offers a route to creating rapid point-of-care (POC) diagnostics. We present a method for multiplexing immunoassays on the surface of a complementary metal oxide semiconductor (CMOS) sensor array integrated circuit (IC) without the use of physical separators such as wells or channels. Major advantages of using a CMOS sensor array include low mass-manufacturing costs, the possibility to multiplex multiple assays on a single IC, and improved signal when averaging multiple sensors, along with providing a platform where wash steps can be incorporated to maximize selectivity and sensitivity compared to paper based lateral flow immunoassay. The device was able to differentiate between samples containing either, neither, or both rabbit anti-mouse (RAM) antibodies

SUBMITTER: Nagy B 

PROVIDER: S-EPMC5974700 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature