The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia.

ABSTRACT:

Background

Platelet transfusions are commonly used to treat critically ill patients with thrombocytopenia. Whether platelet transfusions are associated with a reduction in the risk of major bleeding is unknown.

Patients/methods

Observational cohort study nested in a previous multicenter, randomized thromboprophylaxis trial in the intensive care unit (ICU). The objective was to evaluate the association between platelet transfusions and adjudicated major bleeding events. Platelet transfusion episodes were reviewed for timing of administration, product type, and dose. Major bleeding with and without platelet transfusions was adjusted for severity of thrombocytopenia, use of anti-platelet agents, surgery and other covariates. Secondary outcomes were thrombosis, death in ICU and

SUBMITTER: Arnold DM 

PROVIDER: S-EPMC5974915 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature