Neural and behavioral substrates of disorientation in mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Background

The neural and cognitive substrates of measures of orientation as used in clinical trials and examinations have not been comprehensively examined.

Methods

We studied 473 subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD) at baseline in Alzheimer's Disease Neuroimaging Initiative. Regression analyses at baseline were conducted to find significant predictors of orientation score among cognitive, brain morphometry, and glucose metabolism measures. Mixed model longitudinal analysis was performed to examine consequences of orientation on functional decline, and Cox hazard models examined the risk of conversion to AD in the MCI group.

Results

In MCI and AD subjects, orientation was predicted by poorer neurocognitive performance o

SUBMITTER: Sousa A 

PROVIDER: S-EPMC5975044 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature