Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial.

ABSTRACT:

Introduction

We conducted a phase 1 clinical trial in nine patients with mild-to-moderate Alzheimer's disease to evaluate the safety and dose-limiting toxicity of stereotactic brain injection of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs).

Methods

The low- (n = 3) and high-dose (n = 6) groups received a total of 3.0 × 10⁶ cells/60 μL and 6.0 × 10⁶ cells/60 μL, respectively, into the bilateral hippocampi and right precuneus.

Results

No patient showed serious adverse events including fever during the 24-month follow-up period. During the 12-week follow-up period, the most common acute adverse event was wound pain from the surgical procedure (n = 9), followed by headache (n = 4), dizziness (n = 3), and postoperative deliriu

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC5975048 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature