Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.

ABSTRACT: Macrophage migration inhibitory factor (MIF) is a chemokine-like protein and an important mediator in the inflammatory response. Unlike most other pro-inflammatory cytokines, a number of cell types constitutively express MIF and secretion occurs from preformed stores. MIF is an evolutionarily conserved protein that shows a remarkable functional diversity, including specific binding to surface CD74 and chemokine receptors and the presence of two intrinsic tautomerase and oxidoreductase activities. Several studies have shown that MIF is subject to post-translational modification, particularly redox-dependent modification of the catalytic proline and cysteine residues. In this review, we summarize and discuss MIF post-translational modifications and their effects on the biological properties

SUBMITTER: Schindler L 

PROVIDER: S-EPMC5975065 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature