Blocking mitochondrial cyclophilin D ameliorates TSH-impaired defensive barrier of artery.

ABSTRACT:

Aims

Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous. We sought to investigate whether cyclophilin D (CypD), emerging as a crucial mediator in mitoOS, regulates effects of TSH on ECs.

Methods and results

SCH patients with TSH > = 10mIU/L showed a positive correlation between serum TSH and endothelin-

SUBMITTER: Liu X 

PROVIDER: S-EPMC5975066 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature