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Landscape of copy number variations in Bos taurus: individual - and inter-breed variability.


ABSTRACT: BACKGROUND:The number of studies of Copy Number Variation in cattle has increased in recent years. This has been prompted by the increased availability of data on polymorphisms and their relationship with phenotypes. In addition, livestock species are good models for some human phenotypes. In the present study, we described the landscape of CNV driven genetic variation in a large population of 146 individuals representing 13 cattle breeds, using whole genome DNA sequence. RESULTS:A highly significant variation among all individuals and within each breed was observed in the number of duplications (P?

SUBMITTER: Mielczarek M 

PROVIDER: S-EPMC5975385 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Landscape of copy number variations in Bos taurus: individual - and inter-breed variability.

Mielczarek M M   Frąszczak M M   Nicolazzi E E   Williams J L JL   Szyda J J  

BMC genomics 20180529 1


<h4>Background</h4>The number of studies of Copy Number Variation in cattle has increased in recent years. This has been prompted by the increased availability of data on polymorphisms and their relationship with phenotypes. In addition, livestock species are good models for some human phenotypes. In the present study, we described the landscape of CNV driven genetic variation in a large population of 146 individuals representing 13 cattle breeds, using whole genome DNA sequence.<h4>Results</h4>  ...[more]

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