Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is highly heterogeneous with ~ 60-70% of estrogen receptor positive BC patient's response to anti-hormone therapy. Estrogen receptors (ERs) play an important role in breast cancer progression and treatment. Estrogen related receptors (ERRs) are a group of nuclear receptors which belong to orphan nuclear receptors, which have sequence homology with ERs and share target genes. Here, we investigated the possible role and clinicopathological importance of ERRβ in breast cancer.

Methods

Estrogen related receptor β (ERRβ) expression was examined using tissue microarray slides (TMA) of Breast Carcinoma patients with adjacent normal by immunohistochemistry and in breast cancer cell lines. In order to investigate whether ERRβ is a direct target of ERα, w

SUBMITTER: Madhu Krishna B 

PROVIDER: S-EPMC5975398 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature