GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma is the most common type of lung cancer and one of the most lethal and prevalent cancers. Aberrant glycosylation was common and essential in tumorigenesis, with fucosylation as one of the most common types disrupted in cancers. However, it is still unknown whether genes involved in fucosylation are important for lung adenocarcinoma development and process.

Methods

GMDS is involved in cellular fucosylation. Here we examined GMDS expression level at both mRNA and protein level in lung adenocarcinoma. The impact of GMDS knockdown on lung adenocarcinoma in vitro and in vivo was investigated. Transcriptome changes with GMDS knockdown in lung adenocarcinoma cells were also examined to provide insights into related molecular mechanisms.

Results

SUBMITTER: Wei X 

PROVIDER: S-EPMC5975429 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature